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More than spice: capsaicin in hot chili peppers makes tumor cells commit suicide.
Our overarching hypothesis is that hypoxia not only makes tumor cells resistant to radiotherapy, chemotherapy and in some cases targeted therapy, but also increases their invasiveness and metastatic potential by inducing a select group of genes involved in tissue remodeling.
Glycolysis makes tumor cells resistant to normal death processes.
A dependency on glucose and an inability to use ketones for energy makes tumor cells selectively vulnerable to this therapy.
Thus, suppression of autophagy is followed by the accumulation of ROS, which makes tumor cells more sensitive to apoptosis.
However, the ability of this pathway to perform a variety of functions makes tumor cells to rely on it, illustrating a good example of non-oncogene addiction.
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Moreover our growing knowledge of molecular signaling that makes tumor cell defiant and the poor survival of patients with relapsed or progressive NSCLC reminds us to develop new drugs with better safety profile.
Instead of making healthy cells, they make tumor cells.
Stock C, Schwab A. Protons make tumor cells move like clockwork.
These findings demonstrate the feasibility of utilizing SQ-Gem NPs to make tumor cells more sensitive to Gem and thus provide an efficient new therapeutic alternative for pancreatic adenocarcinoma.
These findings demonstrated the feasibility of utilizing SQdFdC-MP NAs to make tumor cells more sensitive to gemcitabine and thus providing an efficient new therapeutic alternative for pancreatic adenocarcinoma.
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