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The need for a host cell to support the multiplication of the virus makes treatment difficult because the agent must be able to inhibit the virus without seriously affecting the host cells.
Severe scorpion envenomation is rare, which makes treatment difficult to study using conventional controlled clinical trials; and small-scale placebo-controlled trials conducted in tertiary centers are of limited generalizability to the community setting.
What makes treatment difficult is the chaos and danger of an attack -- conditions that can be simulated in moulage drills with actors.
Unfortunately, neuroblastoma develops resistance rapidly to chemotherapy agents and makes treatment difficult.
The current standard treatment consists of surgical resection, radiotherapy, and chemotherapy [3]; however the rapid progression and highly invasive nature of gliomas makes treatment difficult.
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Once inside the system, language and cultural barriers can make treatment difficult.
Most patients are of advanced age with attendant comorbidities, making treatment difficult.
Several NTM strains are resistant to many antimicrobial drugs, making treatment difficult (3 ).
These four countries had in general the highest frequency of resistance to most antimicrobial agents, potentially making treatment difficult.
The wide variety of aetiologies and difficulty in accurately defining the cause of the problem make treatment difficult.
In general, the toxicities are manageable but real, thereby making treatment difficult (Sleijfer et al, 2005; Benjamin 1987).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com