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Moreover, engineering an extra Zn II -binding peptide to the N-terminus of human endostatin makes this molecule more stable and cooperative in the presence of Zn II -binding
The initial bronchoconstrictor effect observed with AZD9164 makes this molecule unfit for its intended purpose.
The multifunctionality of polyP makes this molecule a unique link between living organisms and the inorganic world.
The correlation between the antibody response against it and the asymptomatic status surely makes this molecule an interesting target.
For example, out of the NDL-PCBs, congener 153 is hardly metabolised by the cytochrome P450 (CYP) enzymes, which makes this molecule extremely persistent [ 10].
Li and colleagues [ 47] showed that the linking of N-heterocyclic ring to the A ring of chrysin makes this molecule 16- to 32-fold more active against Escherichia coli and Staphylococcus aureus than its parent compound.
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A dithioamide BHPTC displayed promising antiproliferative activity in several cancerous cell lines, making this molecule an interesting lead compound for the design of new iron-chelating anticancer drugs.
Therefore, the overall results validated each method and make this molecule as a potent MMP-2 inhibitor that blocked the invasion and could bring apoptosis at later stages in K562 cells sparing the normal ones.
Plasmodium vivax Duffy binding protein region II (DBPII) is an essential ligand for reticulocyte invasion, thereby making this molecule an attractive vaccine candidate against asexual blood-stage P. vivax.
The pleiotropic effects of melatonin, combined with its anti-oxidant, NMDA-blocking and anti-inflammatory properties, probably make this molecule an ideal candidate for pre-clinical studies.
Interestingly, the capacity of CD22 to internalize specific monoclonal antibodies was shown to make this molecule an effective target for immunoconjugate therapy of B-cell malignancies [51] [53].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com