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It's mix of the sacred and the profane is touching, funny and strange, and makes this manuscript and its music vividly part of the modern world.
But what really makes this manuscript compelling for a high impact journal is that the findings are synthetic.
A) The referees agree that the novelty that makes this manuscript potentially suitable for eLife is the tubular organisation of the lysosomal network in muscle.
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The author has made this manuscript independently.
With the objective to make this manuscript self contained we decided to include the majority of the proofs.
We acknowledge the positive and constructive criticisms made by the reviewers and the whole editorial board which has helped making this manuscript much more effective.
The title and contents make this manuscript likely to be a copy of the Compendium.
The authors can make this manuscript more interesting than it is in its present form.
However, I feel that many adjustments must be made in order to make this manuscript the high impact paper it should be.
We strongly believe that either of these findings is a significant contribution, and together make this manuscript a critical advance in the field.
In summary, the high quality of the data, the depth of the characterization of CENP-M/H/I/K, and the clarity of the presentation made this manuscript a pleasure to read.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com