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Also, the use of hypertension as a dichotomous outcome results in loss of information, which makes this endpoint fairly insensitive to small effects of noise.
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This is expected to affect the OS observed probably making this endpoint poorly associated to the IPC (see " Results" section).
The weakness of this endpoint results from the difficulty in distinguishing between tumor-related and treatment-related clinical and imaging changes, and this may make this endpoint quite unreliable, with survival potentially being the only definitive endpoint.
This could make the endpoint of PFS less reliable.
Although Gleason scoring is flawed as an indicator of progression, it still remains one of the best indicators of lymph node involvement, treatment failure and death from PCa (NICE, 2008) and as such is routinely recorded in clinic notes making this a well-documented endpoint to assess.
The sophisticated sensors and the development IC make the endpoint detection a hard task.
It would hire a CitySDK Tourism API hosting provider that would make the endpoint available while providing the bar owner with a simple web page for updating the events information.
Lack of information about metal ion levels and functional results because of patients not participating in all follow-ups, the small number of patients, and multiple endpoints made this an exploratory trial.
The flexibility in changing the cut-off also makes the model endpoint independent.
In this Review, we discuss how to: define the importance of endpoints; make endpoints understandable to patients; improve the use of patient-reported outcomes; advance endpoints to parallel changes in trial design and therapeutic interventions; and integrate these improvements into trials and practice.
Solving cell tower security issues by trying to lock every handset would be like trying to make the internet safe by making Symantec Endpoint Security mandatory for all devices with public IPs.
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