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The lack of Smad 4 expression in BIC makes this cell line the perfect negative control for transcriptional regulation of the TGFβ pathway.
These cells in fat body of the larvae have been shown earlier to be capable of surviving complete desiccation even if dissected from the larvae, which makes this cell type a convenient model for studies of anhydrobiosis [37], [38].
This reversible immortalization is unique to this urothelial cell line, and makes this cell line the optimal model for the characterization of cell cycle checkpoint activation, apoptosis, and the DNA damage response in urothelium.
This makes this cell line readily amenable to cellular engineering experiments involving the ectopic expression of these anti-apoptotic proteins [ 16, 18].
Superior chondrogenic differentiation potential of MMSCs makes this cell population be a reservoir of stem cells which offer a promising option treating damaged meniscus through cell therapy.
Several cytokines are released by cells originating from the mesenchymal stem cell family [2] under the control of local and systemic regulating pathways, which makes this cell family a superlative tool if transplanted in vivo.
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Scalability and endurance potentiality make this cell interesting for future high-density and high reliability applications.
The cell was specially designed to include two piezoelectric transducers and two sapphire windows that make this cell well suited to investigate critical behavior of mixtures, using simultaneously the acoustic technique and the direct visual inspection of the critical opalescence.
The relative "ease of use" and the fact that 90-95% of lung cancers are thought to originate in epithelial cells make this cell line an apt toxicity media for geoscientists [54, 55].
Characterizations of astrocytes in culture have pointed to fewer changes, thus making this cell type relatively closer to its initial in vivo state [39].
Taken together, these results make this cell line a good model for investigating cyclin E regulation and its association with chromosomal instability in breast cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com