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What makes these neurons more susceptible to degeneration?
However, their presence makes these neurons relatively insensitive to excitatory inputs.
In addition to gene-gene interactions, it is possible that having a variable toxin load in different sets of motor neurons makes these neurons differentially susceptible to ALS-associated genetic mutations.
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The researchers inserted a gene into mouse embryos that would make these neurons light up when activated.
This has implications for disease pathogenesis in ALS, as motor neurons have a reduced ability to upregulate Hsp70 in conditions of stress, making these neurons more susceptible to cellular insults [71].
Identifying which genes help to make these neurons, and the roles that these neurons play, may help us to understand medical conditions where breathing rhythms become uncoordinated, such as obstructive sleep apnea (Ramirez et al., 2013).
First, light-sensitive genes are inserted into the neurons in order to make those neurons "turn on" when stimulated with the laser.
You will discover that potato tarts are quite lovely when barely warm, and the acid in the tomatoes makes the neurons leap to life.
A single commissure extends from each of the PLM anterior processes to the VNC, where PLM makes presynaptic connections with other neurons, making these anterior-directed processes axon-like.
Dr. McKay's laboratory has developed a technique for making the neurons that are specifically missing in Parkinson's patients.
Not only that, but other genetic tweaks make the neurons actually emit light when active, so the optrode can both influence and monitor the steering pathways.
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CEO of Professional Science Editing for Scientists @ prosciediting.com