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The very feature that makes items worth collecting — scarcity verging on uniqueness — is what makes them problematic as investments.
Vagueness and ambiguity inherent in natural language (textual) clinical guidelines makes them problematic for formulating automated alerts or advice.
To our knowledge, no standards exist that give guidance on how to predict these sounds, which makes them problematic to systematically address.
ODNs with a phosphorothioate (PTO) backbone have been studied as TLR9 agonists since natural ODNs with a phosphodiester (PD) backbone are easily degraded by a serum nuclease, which makes them problematic for therapeutic applications.
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But the increased risks, higher fees and lack of transparency associated with such investments make them problematic.
We loathe rats and find it easier to sweep them from our thoughts than deal with the issues that make them problematic.
But the increased risks, higher fees and lack of transparency associated with such investments make them problematic," Gretchen Morgenson writes in the Fair Game column in The New York Times.
And that can make them problematic -- in the same way as the once-annual Met spring tours, which were abandoned after more than a century in 1986.
Currently available valuation methods, in their entirety, can be costly and time consuming making them problematic for these purposes.
There is a second feature of Samuelson's public goods that would make them problematic in practice: the impossibility of exclusion.
Most of the methods that have been proposed to resolve this problem require diffusion magnetic resonance imaging (MRI) data that comprise large numbers of angles and high b-values, making them problematic for routine clinical imaging and many scientific studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com