While numerous recent methods have emerged that are capable of providing base-resolution of 5-hmC, these methods are sequencing-based, making them laborious and cost prohibitive [ 10, 11].
Lonergan jokes that the reason he switched from novels to plays is that there was less type on the page, which made them less laborious to correct.
In addition to that, the preparation of highly pure and active enzymes is enormously laborious, which makes them an expensive material.
Regularly used blood-based parameters, such as the neutrophil or lymphocyte count and the resultant-derived NLR, are relatively easy to assess without additional laborious efforts, making them attractive parameters for patients' improved individualised risk assessment in RCC (Zahorec, 2001).
Routinely measured blood-based parameters, such as the plasma fibrinogen level, are established, and reproducibly detectable parameters without additional laborious efforts, making them attractive parameters for improved diagnostic or prognostic purposes in RCC (Zahorec, 2001).
Most of them read fluently but one or two struggle, which of course makes it laborious listening, yet at no point does McDonnell correct them.
Although this "bandwidth" problem keeps shrinking as technology improves, it makes listening laborious.
He likes to spend the first half or two-thirds of a work showing his mixed feelings about the traditions of ballet, and he makes a laborious shtick out of treating ballerinas in an anti-ballerina way.
The experience also isn't helped by a mundanely designed menu system, which puts all the key inventory lists and upgrade options on the pause menu (surely a game design no-no), and makes it laborious to select scenic objects you want to restore.
Although the annotated data files exported by alamut-HT and Pindel can be further analyzed by eyes, their size makes this laborious and error prone.
