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They cloned a gene, bre-5, and confirmed that blocking its activity, as a mutation might do, makes the worm resistant to two Bt toxins.
This makes the worm a suitable model organism for delineating human gene function [ 2- 4].
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In this book Tubby introduces Lulu to his worm ranch and informs her that he named them all Lulu, then makes the worms race while he cheers them on.
That's how we got to the discovery that we reported in our BMC Biology paper - it was just an accidental discovery that led to finding that inhibiting folate synthesis in the microbes makes the worms live longer.
The flood of queries was probably intended to make the worm more efficient and help it avoid mailing itself to boxes set up specifically to trap unwanted e-mail, said Jose Nazario, a worm expert at Arbor Networks, a network security company based in Lexington, Mass.
On Wednesday, the latest mutation of Conficker is set to begin communicating with a new set of domain names, potentially making the worm harder to control.
LYS-1 is a putative lysozyme, an antimicrobial protein, so we expected that loss of lys-1 might make the worm sensitive to infection in spite of possible redundancy with lys-2.
I have implied that a mutation that increased the activity of the DAF-2 insulin/IGF receptor might make the worm more fit for environments in which food is abundant.
MIG-2 (YVPTVFDNY) and RhoG (YIPTVFDNY) have one conservative residue difference (V to I), making the worm MIG-2 effector binding sequence identical to Rac while the RhoG effector binding sequence is identical to Cdc42.
Make the worm disappear in the ground.
The London researchers report that they have repeated the experiments with proper controls and found that extra sirtuin does not, after all, make the worms or flies live longer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com