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Increasing complexity makes production of fault-free systems extremely difficult.
Successful production of rFH in this potentially very highly expressing system makes production of therapeutically useful quantities economically viable.
Moreover, the fact that tissue-specific stem cells can each only make a limited number of mature cell types makes production of complex tissues from these cells challenging.
Non-absorbent man-made aggregates like expanded polystyrene (EPS) do not suffer with the disadvantage of water absorption, which makes production of the normal lightweight aggregate concrete difficult.
But, since virtually all responses in nature are polyclonal, it makes production of immensely useful monoclonal antibodies less straightforward.
Unfortunately, the large size of the LRP gene (>10 kb) makes production of transgenic animals that express the whole protein difficult by standard cDNA approaches.
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Though the nibs take 150 steps to make, production of the pens' inner workings has been modernized.
Wolfgang Sawallisch, in urgent need of a ready made production of the Ring that could be mounted at the National theatre, Munich, in a single year, suggested adapting Lehnhoff's cycle, originally created with John Conklin for San Francisco (1983 85).
But the arrangement made production of the "NewsHour" unwieldy at times, and it confused viewers, at least some of whom expect to see the same face or faces every night.
Analysts say Boeing, which has about $80 billion a year in sales, has the financial muscle to weather the problems and make production of the next generation of airliners succeed in an industry familiar with outsize bets.
Expensive instrumentation and multistep pattern transfer procedures make production of these systems challenging and costly.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com