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A live attenuated flu vaccine, which contains weakened versions of the influenza virus, makes mice more prone to bacterial infections in their nasal passages.
Exactly how histamine abnormalities would contribute to the symptoms of Tourette syndrome isn't clear, but State notes that knocking out the equivalent of the HDC gene makes mice more prone to head bobbing, spinning, and other repetitive behaviors.
In addition, poor production of MT makes mice more susceptible to dimethylarsinic acid induced DNA strand breaks in peripheral blood cells (Jia et al. 2004).
It has also been shown that knockout of FRZB, an antagonist of canonical WNT signaling makes mice more susceptible to chemically induced articular cartilage degradation [ 17].
This progestin treatment greatly increases HSV susceptibility and makes mice more uniform in susceptibility than randomly cycling mice [ 26, 28, 36].
However, this theory was recently challenged by contradictory data obtained in various mouse models demonstrating that although the overexpression of several antioxidant enzymes makes mice more resistant to oxidative challenge, it fails to increase their lifespan.
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He argues that instead of spending time and money to make mice more like humans, to "humanize" the mice, a more efficient approach would be to find ways to temporarily reprogram an infected human's immune system to respond more like a mouse's.
One way to bypass that hurdle is to make mice more like humans.
We found that IFN-γ gene ablation made mice more susceptible to inflammation-induced cartilage injury.
Intracerebroventricular infusion of such compounds in adult wild-type mice was well tolerated, lowered tau, and made mice more resistant to drug-induced seizures; tau levels correlated positively with epileptic severity.
81 In regard to tau-lowering approaches, it is encouraging that even partial reduction of tau made mice more resistant to epileptic activity when the reduction was either constitutive 3, 4 or initiated during adulthood.
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