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In addition, the availability of large genealogies makes linkage analysis a potent approach to identify disease loci.
Each Danish citizen has a unique personal identification number, which makes linkage on individual level between several registers possible.
One caveat should be pointed out from the beginning: the variability of gene arrangements within D. willistoni makes linkage mapping an arduous task.
The heterozygous nature of grape cultivars, makes linkage mapping to be performed in F1 populations and maps are constructed for each of the parental genotypes using a pseudo test cross strategy [ 54- 59].
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Lower variability means that they reveal fewer informative meioses, making linkage between markers harder to detect.
The GBS and SNP markers were used to make linkage groups using JoinMap 4.0 [ 30].
In addition, concerns about confidentiality may limit the reporting of specific locations, making linkage to external data more difficult.
Using the national registration number, a unique identifier for each Swedish resident made linkage possible to two of Sweden's six regional breast cancer registers.
Information about the presence of large homozygous segments can reveal gaps and the occurrence of an excessive number of partial linkage groups when making linkage maps in outbreeding plant species.
This multifactorial complexity, along with differing methods for making ex vivo assessments of platelet function, have made linkage between abnormal platelet function on laboratory indices and hard clinical events inconsistent.
The complex genetic background of the species complex has made linkage map construction for these species more challenging than for other polyploid Rosoideae species such as F. × ananassa due to the complex polysomic inheritance patterns observed in autotetraplooid segregating progenies.
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