This discouraged innovation and experimentation, and made it difficult to stage important works of literature.
Limping about and brimming with noxious anger, she makes it difficult to look elsewhere on stage.Mr Rickman makes for a delicately grim Borkman.
The lack of large observational or randomized treatment studies in HIV-2 infected patients makes it difficult to decide at this stage when and which therapy should be started [ 26, 27].
For one thing, citations are slow to appear, so the impact of a piece of work can't really be evaluated until it has been around for a while; the same problem makes it difficult to compare researchers at different stages of their careers.
In addition, the swelling of soft tissue occurring in an injured forearm at the initial stage makes it difficult to create patient-specific features.
Although the mixed-stage infection makes it difficult to examine the effects of CQ treatment on any specific parasite stage, the early reduction in parasitemia fold-change (within 9 h postinfection) suggest that the late-stage P. yoelii and P. berghei parasites were compromised.
Hence, the stochastic nature of health assessment combined with the lack of data in design stages makes it difficult to evaluate the efficiency of a health indicator before the system enters into service.
Lack of best practice strategies during these stages makes it difficult to meet the needs of persons with dementia and reduce the burden on next of kin.
Lack of best practice strategies during these stages makes it difficult to meet the needs of persons with dementia and reduce the burden for next of kin.
On the other hand, the APO injection at the fourth week following the rotenone infusion failed to produce any significant stereotypical circling behavior in MFB-lesioned rats [29], which makes it difficult to assess the model in the early stage.
Due to the common problem that contamination of plant material in infection-stage samples often makes it difficult to study the plant-microbe interactions [ 8, 69], examining Phytophthora life cycle stages such as germinating cysts may be a useful alternative for investigating the transcriptional changes of infection-related Phytophthora genes.
