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The biochemical role of Mrc1 in replication fork progression is unclear which makes it difficult to know its precise role in telomere capping.
Religious scholars say the church's past reticence, even secrecy, in the face of what its leaders have considered persecution, makes it difficult to know how widely the new message is being embraced among members, or how long it will last.
And this makes it difficult to know how to feel about the latest wave of investigations.
It makes it difficult to know which set of critical coordinates to apply.
A hybrid of fiction and documentary, the film makes it difficult to know what is real.
Justice Kennedy's record makes it difficult to know for sure how he will vote in this case.
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31, making it difficult to know how much money Mr. Perry's campaign has left.
The problem is that the truth made it difficult to know what to hope for.
Those areas, according to Birchenough, made it difficult to know where players could and could not ground their club.
Some apps will work only with particular versions, making it difficult to know exactly what you are getting.
For European companies, the protracted legislative process has made it difficult to know what compliance and risk management structures they will need to develop — and at what cost.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com