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One problem is that van Marwijk's formation makes it difficult to accommodate on-fire Klass-Jan Huntelaar, who scored against England in February.
In addition, using CCPS increases the rate of inbreeding [ 8] and makes it difficult to accommodate non-additive gene action [ 6].
One of the controversial human occupation sites in question, Monte Verde in Southern Chile, is now largely accepted as dated at about 14500 YBP, which makes it difficult to accommodate on the Clovis first model.
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These deficiencies have make it difficult to accommodate changes of social, industrial and employment environment in customized fashion.
That lesson had a strong logistical component as well: The small size of many North American bathrooms made it difficult to accommodate both a regular toilet and a bidet, and plumbing in homes wasn't a simple thing to change once it was standardised for the non-bidet flush toilet.
The early 'deterministic' models of transcriptional activation that postulated the existence of a well-orchestrated sequence of events involving ready-to-use core holoenzymes 27 made it difficult to accommodate this diversity of components.
Usually a lot of economic activity slows down during the winter — when frigid, snowy weather makes it difficult to build, for example — then picks up in the spring, when the weather is more accommodating.
"It obviously makes it difficult to shop".
"It makes it difficult to raise money".
That makes it difficult to recommend solutions.
It makes it difficult to form coalitions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com