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The study "tackles a question that is of great pragmatic importance for vaccines," says virologist Gary Nabel in Cambridge, Massachusetts, who is the chief scientific officer at Sanofi, which makes influenza vaccines.
The findings, while an encouraging proof of principle, show the urgent need to develop ways to use vaccines more sparingly and to replace chicken eggs--the limiting step in current flu vaccine technology--with cell-based production systems, says vaccine researcher Jeroen Medema of Solvay, another company that makes influenza vaccine.
The wealth of genomic sequence information makes influenza an attractive model for studying sequence change over time in a rapidly evolving system [5], [6].
This makes influenza virologists and healthcare officials fear that further mutations in the 2009 A(H1N1) virus could also lead to a potentially more dangerous second wave in subsequent months.
This makes influenza A virus strains able to evade neutralizing antibody from prior infection or vaccination.
Outside an influenza epidemic the absence of cough and fever (> 37,8°C) makes influenza 14 times less likely in ILI patients.
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Manufacturers use different techniques in making influenza vaccines.
He said scientists were exploring two new ways to make influenza vaccine.
This technology has been used to make influenza vaccines for 60 years, and it has an excellent safety record.
The suspension of Chiron's license to make influenza vaccine at its Liverpool factory caught American health officials by surprise.
Protein Sciences is one of several small companies trying to make influenza vaccines by methods that are faster than growing them in chicken eggs, the technique now generally used.
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