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Because the AA' loop makes few contacts to the main body of the IL-3 structure, it is highly exposed and flexible.
During the adenylation reaction, the cysteine domain of the E1 adopts an open conformation in which it makes few contacts with the active Rossmann-type subunit, and the catalytic cysteine residue is separated from the carboxyl terminus of the bound Ubl by over 30 Å [ 8, 32, 37, 38].
Similar(58)
However, in the N-terminal domain the S1' sub-site makes fewer contacts with the lysyl chain of lisinopril (Figure 4).
The removal of the side chains of Ser237 and Arg276 also allow the aminothiazole ring to flip 180° into a position that makes fewer contacts with the enzyme.
The 220-loop of NY18 HA makes fewer contacts with the human receptor and NY18 HA also lacks the longer side chain of Glu for optimal contacts with the avian receptor.
While retina neurites made contacts with a nearby COS cell aggregates transfected with a control plasmid, they had little neurite outgrowth from regions near to Db-expressing COS cell aggregates and made few contacts with these cells.
However, it is possible that transients actually make fewer contacts with other coyotes compared to residents, whose frequent interactions among pack-mates may provide the best opportunity for pathogen transmission.
In general, women made fewer contacts in 32 seconds irrespective of whether the task was performed with the right (F 1,52) = 15.597, p≤0.001) or the left hand (F 1,52) = 7.747, p = 0.007).
Indeed, the packing of residues is so precise that we may think of proteins as solutions to 3D "jigsaw puzzles," wherein the outside pieces make fewer contacts with other pieces and are therefore more free to change, whereas the buried inside pieces are heavily constrained by their densely packed environment (Richards 1974).
Changes in behaviour that result in individuals making fewer contacts over the course of a day than would have been the case prior to the behaviour change is one form of social distancing that might occur during a severe influenza pandemic.
Compared to other bHLH structures, (SCL E47 bHLH makes fewer overall contacts to DNA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com