Sentence examples for makes extensive contacts from inspiring English sources

Shepherdin makes extensive contacts with the ATP pocket of Hsp90, destabilizes its client proteins, and induces massive death of tumor cells by apoptotic and nonapoptotic mechanisms.

This small VP5 domain makes extensive contacts with a VP4 subunit in an adjacent helical turn (Fig. 3c) as well as with the C-terminal domain from two other VP5 subunits in the same helical turn.

Nevertheless, it is located in a similar position to the RNF125 C2HC ZnF (Fig. 8D) and also makes extensive contacts with the first Zinc binding loop of the RING domain (Fig. 8E).

Binding to Rac1 induces a dramatic stabilization in SptP of a four-helix bundle that makes extensive contacts with the Switch I and Switch II regions of the GTPase.

TERT contains an essential and universally-conserved telomerase RNA-binding domain (TRBD) that makes extensive contacts with TR and represents the major TR-binding domain [46], [47].

PTPA makes extensive contacts with structural elements surrounding the PP2Ac active site.

Unlike any previously described antibody antigen structure, the conserved framework region of the antibody makes extensive contact with the viral surface.

Crystallographic studies have revealed that, unlike AlkB, ALKBH2 makes extensive contact with both strands of duplex DNA.

In S. cerevisiae, each subunit of the Ubp8-Sgf11-Sus1-Sgf73 contact makes extensive contact with all other subunits and all four components are required for DUB activity in vitro and in vivo (Lee et al. 2009 ; Weake et al. 2008 ).

The L15 N-terminal extension also make extensive contacts with the RNA helix, 2427 to 2462, which was potentially displaced by L10e/L16 as noted above and shown in Figure 3.

An 18-residue XIAP peptide binds the catalytic groove of caspase-7, making extensive contacts to the residues that are essential for its catalytic activity.