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For large-scale fabrication of hybrid structures, one relies on controlling the various types of non-covalent interactions, long-range (i.e. electrostatic) and short-range (i.e. van der Waals) [8], [9], [10], [11], typically between nanoparticles and proteins, in which chemical and structural complexity makes elucidation of the assembly mechanism difficult to fully characterize.
Additionally, class II HDACs seem to have additional levels of regulation, which makes elucidation of the mechanism of gene transcription regulation more complicated.
As a result, the burden of age-related diseases and infertility makes elucidation of the pathobiology of aging an urgent priority.
However, in contrast to Mendelian traits (traits that are caused by a single locus), quantitative traits are established by multiple interacting genetic loci, which makes elucidation of their genetic basis much more difficult [ 17].
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It is expected in future studies researchers can seek to explore the cellular events occurring in natural product-induced autophagy, which makes elucidation on action of autophagy in a more mechanistic way.
Moreover, the common binder matrices are far from pure, making elucidation of the underlying emission mechanisms somewhat challenging, though nonetheless functional.
Spatial patterns are influenced by many, often interacting, factors making elucidation of key drivers difficult.
In such monocotyledons, the various chemical compositions and structures of the individual cell types make elucidation of the recalcitrance in these plant materials more difficult [ 3, 9].
However, DA-9801 is a herbal extract and, this has made elucidation of a single effective component and its plasma concentration difficult.
Metabolic differences between species, organs and tissues make elucidation of DA metabolism more complicated; the multitude of different models used make it hard to combine the different findings [ 88, 131, 132, 138].
Decreased transcription of the BRCA1 gene has previously been observed to occur in sporadic breast tumours, making elucidation of the mechanisms regulating the expression of this gene important for our understanding of the etiology of the disease.
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