A detailed parametric study is made, elucidating the individual roles of permeability and degradation rates.
The significant strides that have been made in elucidating the mechanisms of pathogenesis in CTCL have allowed for the development of an extensive repertoire of targeted therapies.
Recent advances have been made in elucidating the mechanism of toxicity to hair cells and have demonstrated substantial apoptosis within twelve hours of exposure to aminoglycoside in guinea pig [ 16] and initiated within three hours of noise exposure [ 17].
In the two decades since the discovery of the first flavin-dependent halogenase (FDH), great strides have been made in elucidating the diversity of enzymes in this class as well as their structures and functions.
Significant advances have been made in elucidating the force-producing interaction between actin and the myosin-S1-subunit, including the localization of the most probable molecular site of power stroke initiation.
Therefore, considerable efforts have been made in elucidating the signalling pathways leading to the expression of those mediators.
Substantial advances have been made in elucidating the pathogenesis of SSc, which has been facilitated in part by the development of more appropriate animal models.
Significant advances have been made in elucidating the role of genetic factors in nicotine dependence and response to smoking cessation treatment.
Although significant strides have been made in elucidating the multifaceted mechanisms associated with many cardiometabolic complications [ 1, 2], much still has to be done.
During the past several years, significant progresses have been made in elucidating the mechanisms of plant sex determination, an important and fundamental developmental process of flowering plants, as exemplified by cloning several major sex-determining genes in cucurbit species [ 6, 7, 38].
