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Importantly, CAR exhibits remarkable species selectivity in its ligand binding and activation profiles, which makes direct extrapolation of findings from mouse to human extremely risky.
The dominance of hypodynamic models in the animal literature makes direct extrapolation of the effects of fluid resuscitation to human sepsis particularly problematic.
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We have read both of these excellent papers carefully, and while on the surface they appear to be relevant to the current study because they also deal with active and passive behaviors, there are considerable distinctions in design and behavioral measures that make direct extrapolation to our work difficult.
Therefore, one should be cautious about making direct extrapolations based on observations with aqueous test systems or vegetable oils.
However, we would like to stress that as our data stands, we do not make direct extrapolations to the human muscle or DMD patients, but the working model arising from our data raises new questions and opens a new avenue for more applied research to follow.
It makes direct line cuts.
"One shouldn't just make this direct extrapolation to what the risk on land actually is". .
The disease known as sJIA in Japan is very similar to that reported in Caucasians, but not enough is known about the phenotypes and genotypes to make a direct extrapolation of drug response.
The paper uses data from different sources and although we make direct comparisons, readers should consider the extrapolations that we have made.
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