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The trial was designed and analysed as an individually randomised trial, but practice variation probably makes a modest difference: adjustment for practice as a covariate did not alter the inferences, and adjustment for clustering by practice led to slightly reduced significance for symptom severity in the clinical score group but slightly increased significance for symptom resolution.
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This suggests that when analysing pooled data across different hospitals case-mix adjustment may make a modest difference to the analysis.
But the proposals could make a modest difference.
In Syria, it seems to me that cruise missile strikes might make a modest difference, by deterring further deployment of chemical weapons.
Today, I'm dismayed that so many liberals, disillusioned by Iraq, seem willing to let an average of 165 Syrians be killed daily rather than contemplate missile strikes that just might, at the margins, make a modest difference.
But even though it remains unclear how dire the outlook is -- on Friday the government reported that the economy expanded at a reasonably healthy 2percentt annual rate in the first three months of the year -- the stimulus package has ballooned to somewhere between $60 billion and $85 billion, enough to make a modest difference.
It should be borne in mind that owing to the correlations among breast cancer risk factors, the addition of a new risk factor, however powerful, to a model already containing several risk factors will invariably make a modest difference to prediction measures such as AUC.
And while some prominent manufacturers, like Dell and Hewlett-Packard, have agreed to recycle their own equipment, such programs have so far made only a modest difference.
Scientists who oversaw government culling trials and made economic assessments concluded last year that killing badgers would make only "a modest difference" in TB in cattle, and could not meaningfully contribute to future control of the disease.
The other rate changes would make only a modest difference to Trump, who at least in 2005 earned relatively little (about $10.8 million) from wages, interest and dividends.
But because these negotiated ceilings are so much higher than the tariffs countries actually impose, even quite big cuts can make only a modest difference to trade.In rich countries, for example, the farm tariffs actually imposed would have fallen from 15% on average to 11%, according to the two economists.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com