Your English writing platform
Discover LudwigExact(50)
In the T. thermophilus RF1 crystal structure [ 8] the switch loop in the active conformation makes a hydrogen bonding interaction to A-1493 of the ribosomal decoding center.
In contrast, in the model of the active conformation of the TSHR TMD, Asn6747.49 makes a hydrogen bond with Asp4602.50 (Supplementary Table 6, Fig. 3c).
HBY 097 makes a hydrogen bond with the thiol group of Cys181 that helps the drug retain potency against the Tyr181Cys mutation.
It is noteworthy to mention that 1HNMR have also shown a singlet signal at δ 15.28 ppm which can be assigned to the OH group which makes a hydrogen bond.
In the inactive state, TSHR Asp6336.44 makes a hydrogen bond with Asn6707.40 (in TM7), a possible water-mediated hydrogen bond with Asn6747.44 (in TM7) [39] and an induced dipole and hydrophobic interactions with Leu5123.43, from TM3.
The OHad promotes water dissociation on the flat surface because it makes a hydrogen bond with a water molecule adsorbed on the Pt top site; however, on the pitted surface, water dissociation is prohibited because of an unfavorable formation of a hydrogen bond between the OHad on the bridge site and the H2O on the top site.
Similar(8)
In compounds 1 and 2, the sulfonate group mimics the association of the carboxylate moiety and makes a hydrogen-bonded ring of graph-set notation R22 8) with the PMN and AMPY cations.
In Sst2, the corresponding residue is Thr319, which makes a hydrogen-bonding contact using its side-chain OH group with the backbone NH group of Leu73 of ubiquitin as seen in the structure of Sst2cat Ub (and other ubiquitin-bound structures reported here, as well).
This is interesting because when ubiquitin is bound to Sst2cat, Thr319 makes a hydrogen-bonding contact with Glu322 (distance of 2.6 Å between Oγ of Thr and Oδ of Glu), which is the only contact the latter residue makes with a protein atom.
In notable past failures, the C.I.A. misjudged how fast the Russians could make a hydrogen bomb, never spotted the vast size of the Soviet germ warfare program and failed to realize how close Saddam Hussein was to making nuclear weapons before the first gulf war.
However, significant technological breakthroughs are necessary for making a hydrogen economy feasible.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com