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The phrase "makes a great difference" is correct and usable in written English.
You can use it when you want to express that something has had a significant impact. For example: "Having a mentor makes a great difference when learning a new skill."
Exact(24)
I want to say that that makes a great difference.
"That always makes a great difference to a game.
"It makes a great difference to us and certainly helps our ability to promote a movie".
"The absence of an effective opposition makes a great difference," said Takashi Inoguchi, a political scientist at Tokyo University.
The drag force of hypersonic vehicles and missiles makes a great difference to their final performance and hence to their design process.
Indeed, Ms. Crockin said, the fact that an embryo is in a freezer rather than in a womb makes a great difference.
Similar(36)
It is caused by the temperature differences between land and ocean, and in general, a larger landmass makes a greater difference, which makes a more extreme monsoon.
Thus it makes a greater difference to decrease the probability of a negative outcome from 2 to 1 per cent than to decrease it from 51 to 50 percent.
Five years would probably make a great difference.
I think he can make a great difference".
Bethnal Green has equipment which can make a great difference.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com