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The WikiPathways web service could be used as framework for building data analysis tools that make use of pathway information.
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Elucidating possible mechanisms for this metabolite might make use of pathways already defined for familial disease.
For example, most classification and regression methods for microarray data are based on the whole set of genes and have not made use of pathway information.
Added to these models, a PGDB for C. reinhardtii has been made available as ChlamyCyc [ 86] making use of Pathway Tools platform and thus making the investigations of the metabolic and regulatory networks of such algae far more at hand.
It is unknown whether MSCs make use of this pathway to regulate immune cells.
She knows the huge difference an Ivy League education made in her life and has the sense that minorities should make use of those pathways and they shouldn't be considered out of reach for people in inner cities".
Opportunities exist to make use of natural pathways for delivery of therapeutic entities, in particular to develop safe and effective methods for gene therapy, although past attempts to design non-viral nuclear delivery systems have met with limited success.
During embryogenesis, developmental mechanisms akin to those discovered in the vertebrate lung and vasculature make use of signaling pathways such as fibroblast growth factor (FGF) signaling to sculpt this complex tracheal network of interconnected tubes (Ghabrial et al., 2003; Javerzat et al., 2002; Metzger et al., 2008; Uv et al., 2003).
Linking pathway deregulation with sensitivity to therapeutics that target components of the pathway provides an opportunity to make use of these oncogenic pathway signatures to guide the use of targeted therapeutics.
As described above, advanced human cancer cells that retain TGF-β/SMAD signaling but lack tumor suppressive responses can make use of the SMAD pathway to their advantages, and via SMAD3/SMAD4 stimulate pro-invasive and pro-metastatic target genes (for example, IL11, CTGF, CXCR4) and reprogram (EMT) phenotypes (Aggarwal and Massague, 2012).
Our study provides an example of simulating and designing biological dynamics in silico and indicates how to make use of the native pathway's features in this process.
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