Sentence examples for make tumour cells from inspiring English sources
Upon binding to the type II IFN receptor, IFN-γ triggers the JAK/STAT signalling cascade that leads to the expression of a large array of interferon induced genes which can cause growth arrest, cell death or make tumour cells to upregulate MHC-I expression and antigen presentation, thus becoming more susceptible to MHC-restricted cytolytic killing24,25.
Indeed, PARP inhibitors may make tumour cells more sensitive to cancer therapies [ 70- 72].
A low oxygen concentration is known to make tumour cells resistant to radiation therapy and chemotherapy [ 2].
Taken together, EpCAM antibody treatment seems to make tumour cells recognisable for immune response in vivo, and the antineoplastic effects of the antibody require the immune response.
Furthermore, it has been reported that the inhibition of GJIC can make tumour cells independent from growth-restraining factors from neighbouring cells (Yamasaki and Naus, 1996; Chipman et al, 2003).
Importantly, the down-regulation of CREB3L1 diminishes doxorubicin-induced effects on cell proliferation, whereas overexpression of CREB3L1 makes tumour cells more sensitive to doxorubicin.
While this cardinal feature generally makes tumour cells more resistant to apoptosis than normal cells, it concomitantly presents tumour-specific attributes that can be exploited in the design of novel therapeutics.
Recent data suggest that the anti-oxidant system of tumour cells may be altered during cancer progression, making tumour cells more sensitive to ROS damage (Mahéo et al, 2005; Vibet et al, 2008; Sun et al, 2009).
Targeted knockdown of HO-1 expression led to pronounced growth inhibition of pancreatic cancer cells and made tumour cells significantly more sensitive to radiotherapy and chemotherapy (Berberat et al, 2005).
These data suggest that the hypoxic induction of VEGF during serum deprivation could be an adaptive response, making tumour cells less susceptible to apoptosis-inducing stimuli prior to initiation of new blood vessel formation [ 17].
Interestingly, however, it has also been reported that the down-regulation of HLA class I makes tumour cells more sensible to natural killer (NK) cell attack (Ravetch and Lanier, 2000), so that the loss of HLA class I might be a disadvantage for the tumour.
