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Normally, BRCA genes help prevent cancer; mutations disable them and make tumors more likely.

Meanwhile, Dr. Halmos' research team also has discovered ways to make tumors more susceptible to conventional chemotherapeutics, as he showed in a paper published in Carcinogenesis.

This study represents an important step in understanding how changes that disable this gene would make tumors more aggressive, says Monte Winslow, a senior postdoctoral associate in Jacks' lab and lead author of a paper on the work appearing in the April 6 online edition of Nature.

On the other hand, a forced transdifferentiation to a complete transformation may make tumors more sensitive to chemotherapy and radiation than the original tumor.

Radiosensitizers can also be delivered to solid tumors through the use of nano-carriers to make tumors more vulnerable to external radiation.

The results of clinical trials in lung cancer, led by Johns Hopkins Charles Rudinn and published late last year in Cancer Discovery, also indicate that the drugs make tumors more responsive to standard anti-cancer drug treatment.

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Published in the Jan . 17issue of Cancer Cell, the study's findings suggest that antiangiogenic therapies — which shrink cancer by cutting off tumors' blood supply — may be inadvertently making tumors more aggressive and likely to spread.

McConway, an expert on the use of statistics in biological and medical research, said that since the tumors examined in the study are relatively rare, it would take more than 90 rats in each group to see whether radiation exposure made tumors more likely.

On the other hand, hyperactivation of oncogenic pathways makes tumors more susceptible to metabolic inhibition.

These findings demonstrate the feasibility of utilizing SQ-Gem NPs to make tumor cells more sensitive to Gem and thus provide an efficient new therapeutic alternative for pancreatic adenocarcinoma.

These findings demonstrated the feasibility of utilizing SQdFdC-MP NAs to make tumor cells more sensitive to gemcitabine and thus providing an efficient new therapeutic alternative for pancreatic adenocarcinoma.

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