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A second fast-growing field is the detection of the DNA flaws that make tumor cells grow far more rapidly than regular cells.
But flaws in either gene also make tumor cells vulnerable to PARP inhibitors, because the drugs further impair tumor cells' DNA repair machinery.
These findings demonstrate the feasibility of utilizing SQ-Gem NPs to make tumor cells more sensitive to Gem and thus provide an efficient new therapeutic alternative for pancreatic adenocarcinoma.
These findings demonstrated the feasibility of utilizing SQdFdC-MP NAs to make tumor cells more sensitive to gemcitabine and thus providing an efficient new therapeutic alternative for pancreatic adenocarcinoma.
The second Chi-Med drug in trials, a radiosensitizer for head and neck cancer, helps make tumor cells more receptive to radiation by increasing the amount of oxygen in the cells.
These alterations are postulated to make tumor cells vulnerable to a further oxidative stress.
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Emerging evidences show that tumor-educated host microenvironment cooperates with tumor cells during the multiple stage of metastasis, making tumor cells evade immune attack, resistant to apoptosis, and proliferate in distant organ (Liu et al., 2016; Quail and Joyce, 2013).
Together, these findings demonstrated that the modulation of the length of nanoassemblies polyisoprenoyl moiety made tumor cells more sensitive to gemcitabine treatment without flagrant toxicity, thus providing a significant improvement in the drug therapeutic index.
Glycolysis makes tumor cells resistant to normal death processes.
It can induce additional peptide loading onto tumor cells, making tumor cells more antigenic for specific CTL activity.
It can induce additional peptide loading onto tumor cells, making tumor cells more antigenic for specific cytotoxic T-lymphocyte activity.
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