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Unfortunately, the underlying molecular dynamics simulations make this protocol quite time-consuming.
High catalytic activity and excellent selectivity of catalyst in water medium make this protocol a green way for production of fine chemicals.
This catalyst provides clean conversion; greater selectivity and easy work-up make this protocol practical and economically attractive.
The widespread applicability of the process, here described, to different COMT sources could make this protocol highly useful for all studies requiring purified and active COMT proteins.
The high response rate and good long-term survival, as well as the tolerable acute and cumulative toxic effects, associated with use of etoposide, methotrexate and dactinomycin, alternating with cyclophosphamide and vincristine, make this protocol, or one of its variants, the current initial treatment of choice for patients.
"It took a bit longer because to make this protocol, the discussion was a little bit complicated…there were many ideas that emerged at the time of developing this protocol, some people had experience (working) in Africa, they would say their experience" (MoH Malaria Officer).
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The simple, rapid and sensitive benign process makes this protocol promising for recognition of phenylglycinol enantiomers.
The use of microwave irradiation under solvent free conditions makes this protocol practical and environmentally friendly.
The only by-product of the new procedure is aqueous sodium nitrate which makes this protocol the cleanest route yet to nGO.
Obviously, PIM-SSM is simple to implement for network operators thanks to the source-specific mode (SSM) [1], which makes this protocol ideal for IPTV.
Making this protocol resilient to IP changes and temporary disconnections is a valuable adaptability capability in a mobile applications environment, where network connections are commonly not fully reliable.
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