Sentence examples for make this problematic from inspiring English sources

Can anyone make this problematic piece work?

Standard tumor sampling methods make this problematic, as it is common to have a substantial proportion (typically 30-50%) of a tumor sample comprised of histologically benign tissue.

Initially, it may seem that the YO-CNAT [ 4] can also be used for estimating the risk for future care needs of juvenile non-offenders, but three important issues can make this problematic.

Spatiotemporal instability (Curtis et al. 2013) in the Fukushima GSV dataset makes this problematic, however.

The high compressibility of the mobile phase in SFC however makes this problematic.

The use of combined therapy makes this problematic.

However, a wide range of delusional beliefs have been reported in patient populations [ 22] making this problematic.

But local issues often make this instantly problematic, he says – the fact that Weatherley is standing down, for instance, means Hove Tories can't count on a small but significant "incumbency bonus" that may be a factor elsewhere.

However, as for dental enamel thickness, a number of Late Miocene apes (such as Oreopithecus) also have a reduced or absent canine premolar honing complex, which might also make this a problematic diagnostic trait (McNulty 2010).

Although Sony is calling its plan "One," there are actually five different areas that it says it will tackle under its new management (that in itself could make this strategy problematic).

However, the variable quality of supernumerary human embryos and the lack of functional measures of blastocyst maturation make this research problematic.