Sentence examples for make this pathway from inspiring English sources
These properties make this pathway an extremely attractive target for intervention.
These observations make this pathway an attractive target for pharmaceutical investigation, with a number of MEK inhibitors having been developed and evaluated clinically.
Genetic aberrations of this pathway, such as PIK3CA mutations, loss of PTEN, and AKT activation, make this pathway a commonly activated one in breast cancer.
The multiple members of the IGF axis, the lack of known receptor activating mutations and the ligand-dependent nature of IGF signal transduction make this pathway difficult to model both in vitro and in vivo.
These findings, and the fact that PI3K and other kinases in the PI3K pathway are highly suitable for pharmacological studies, make this pathway one of the most attractive targets for therapeutic intervention in cancer treatment [ 3].
Despite these similarities, several features of nuclear RNAi in C. elegans make this pathway a unique model system to explore novel mechanisms of RNA-mediated chromatin silencing and its roles in developmental regulation.
Careful selection of commercially available materials and mild conditions made this pathway amenable to scale up.
The NHEJ pathway is frequently upregulated in several solid cancers as a compensatory mechanism for a separate DSB repair defect or for innate genomic instability, making this pathway a powerful target for synthetic lethality approaches.
In conclusion, our data demonstrated the time dependent response of the Nrf2-antioxidant system to a single treatment of scrotal heat in the mouse testes, making this pathway a potential target for new drugs designed to prevent oxidative stress-induced male infertility.
Importantly, bacterial and fungal FAS s) are distinct from human ones, which makes this pathway an attractive target.
The observation that the insulin/IGF-1 signalling pathway is affected (although not equally) in PSP, FTD and PiD makes this pathway an interesting target for further research.
