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Therefore, the overall results validated each method and make this molecule as a potent MMP-2 inhibitor that blocked the invasion and could bring apoptosis at later stages in K562 cells sparing the normal ones.
The pleiotropic effects of melatonin, combined with its anti-oxidant, NMDA-blocking and anti-inflammatory properties, probably make this molecule an ideal candidate for pre-clinical studies.
Interestingly, the capacity of CD22 to internalize specific monoclonal antibodies was shown to make this molecule an effective target for immunoconjugate therapy of B-cell malignancies [51] [53].
The physical properties of [F]FDG make this molecule especially useful for intraoperative tumour imaging.
As pointed out by Murray et al (2011) these features make this molecule a promising biomarker for testicular GCTs.
The role of RAI3 in cancer and its localisation in the plasma membrane make this molecule an interesting potential target for antibody-mediated therapy.
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A dithioamide BHPTC displayed promising antiproliferative activity in several cancerous cell lines, making this molecule an interesting lead compound for the design of new iron-chelating anticancer drugs.
Moreover, engineering an extra Zn II -binding peptide to the N-terminus of human endostatin makes this molecule more stable and cooperative in the presence of Zn II -binding
Plasmodium vivax Duffy binding protein region II (DBPII) is an essential ligand for reticulocyte invasion, thereby making this molecule an attractive vaccine candidate against asexual blood-stage P. vivax.
The initial bronchoconstrictor effect observed with AZD9164 makes this molecule unfit for its intended purpose.
The correlation between the antibody response against it and the asymptomatic status surely makes this molecule an interesting target.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com