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All these features make this gene a promising candidate for BP regulation.
The human-specific nature of cerebral dominance and the evolutionary history of PCDH11X/Y make this gene pair the leading candidate for the right-shift factor.
The presence of at least sixteen different missense mutations between B6 and D2 (including three that are predicted damaging) make this gene a likely candidate.
Of course, this matching would make this gene unimprinted, at which point it would begin to be selected according to maximize non-imprinted inclusive fitness.
The co-incidental spatiotemporal expression of Zic2 and Sert in the mouse retina, together with the expression of Sert in ipsilateral but not in contralateral RGC axons, make this gene an excellent candidate as a Zic2 downstream effector molecule.
This together with the fact that lactoferrin is one of the safest and occurs in the diet of humans; make this gene a potentially highly desirable candidate to introduce plant resistance against diseases.
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More recently, mutations in ARID2 were identified in NSCLC (7.3%), making this gene one of the most frequently mutated in this type of cancer (Manceau et al., 2013).
The known anti-apoptotic role of BCL-XL isoform (Boise et al., 1993) made this gene the prime candidate as a driver mutation in the 20q11.21 region.
Moreover, labelled MSCs stably express the hPAP gene, thus allowing cell detection by classical histochemical methods, making this gene a useful tracking tool for further in vivo MRI validation.
Although it is also possible that the PLCB1 gene itself is regulated by PAX6 and CTCF, the fact that PLCB4 is directly related to circadian control makes this gene a more likely candidate.
Normal bone loss following ovariectomy made this gene uninteresting as an osteoporosis drug target.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com