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The role of let-7 and LIN28 in inhibiting or enhancing oncogenic signaling via RAS, NF-κB, and high mobility group AT-hook 2 (Hmake) make these pathways attractive therapeutic targets [88]– [90].
The potent effects of elevated cAMP and Gq-coupled receptor activation, together with the L cell-specific expression of receptors such as Gpr40, Gpr120, Gpr119, and Tgr5 in the intestine, make these pathways exciting targets for the future development of therapeutic L cell secretagogues.
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"So I made these pathways".
Similarly, the contribution PI3K/Akt and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway deregulation exerts on MM and drug resistance also makes these pathways attractive targets for co-inhibition with MEK specific agents.
Furthermore, recent publications indicate that CD95-induced NF- κB and MAPK activation are also important for phagocyte attraction and generation of the 'find me' signal via the secretion of cytokines, making these pathways responsible for the proper execution of apoptosis as well.
The close relation between the ubiquitin-mediated proteolysis and NF- kB and their relevance to a wealth of human disorders make these two pathways attractive candidates for DS pathogenesis.
Looking at the genes that make up these pathways, many are found in more than one pathway.
A significant outcome of this study is that, although the pathways affected in early and late AD are identical, the expression of the individual genes that make up these pathways is highly variable in the brain of different patients.
The pathways that make these non-protein molecules have many steps, sometimes dozens, each controlled by a particular enzyme.
For example, with the exception of a few proteins, representation of glycolysis and the TCA cycle was complete, which implies that the proteins making up these pathways are part of the core proteome [52] associated with Shewanella.
The computer, without any intervention of the interviewer, automatically makes all these pathways.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com