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Therefore, except for the number of rotatable bonds that may make the sampling and scoring of the ligand difficult with Glide, Surflex and Gold, there is no real influence of the properties of the protein or the ligand on the success of the four programs in finding the right pose.
The high temperature was chosen to make the sampling nearly independent of S gap (> 0.95 expected acceptance probability).
Recordings targeted the superficial layers of cortex at an estimated depth of 300 800 μm to make the sampling comparable with the optical imaging data.
On the downside, these approaches generally require a great deal of data, very good knowledge of the species distribution, and make the sampling design critical as it must be representative of the postdispersal distribution of individuals (evaluation of long-distance dispersal might be especially difficult due to constraints in the size of the study area).
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The cost of mounting the last show -- models, invitations, renting space -- came to $20,000, plus $85,000 to make the samples.
The authors acknowledge that participants had to be judged mentally fit to consent, follow instructions and keep appointments, which may make the sample somewhat unrepresentative.
"This would make the samples technically non-compliant but not at a level that would pose any public health concern".
This was done to make the samples conductive.
RDA is designed to make the samples match their nearest subspaces.
Moving further away from the point of receipt would make the sample size become very small.
Electroless plating of non-conducting materials needs, prior to the metal deposition itself, to make the sample surface catalytically active.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com