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The phrase "make the most difference" is a correct and common phrase in written English.
It can be used to mean to have the greatest impact or effect on a situation or outcome. Example: "Your support and donations make the most difference in the lives of these children." In this example, the phrase is used to convey that the support and donations have the greatest impact on the lives of the children. It can also be used in other contexts, such as: - "Changing your diet can make the most difference in improving your overall health." - "This new policy will make the most difference in reducing our company's carbon footprint." - "Karen's presence at the meeting made the most difference in calming everyone down." Overall, the phrase "make the most difference" is versatile and can be used in various situations to emphasize the idea of having the biggest impact or effect.
Exact(60)
Which Jobs Make the Most Difference?
It's how philanthropies can leverage their limited dollars to make the most difference possible.
Our responsibility is not to heed the catchiest slogan, but to make the most difference.
In what sort of countries does having "a visiting royal" make the most difference?
What scientific advance would make the most difference to your daily life?
Where you can make the most difference may not be immediately obvious, Baker says.
My aim has always been to work where I can make the most difference.
And The Illuminati™ knows in advance where those hundreds of votes can make the most difference?
Subsidies need to be directed to where they will make the most difference.
Matters that work, that do not and would make the most difference to the success of contracts were identified.
We could tell people what we needed and they'd know where they could make the most difference with their donations.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com