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Therefore, we will make the estimate of the function Phi=frac{1}{2}v^{2}+frac{1}{2}j_{I} omega^{2}+c_{v}theta, (74) adapting the procedure used in the proof of Lemma 2.4 in [20], p.203.
If there is high between-individual variation in slopes, then taking more measurements from the same individual will make the estimate of this particular slope more precise.
However, while interpreting these results one should keep in mind that there were some limitations of this meta-analysis with regard to heterogeneity and number of studies, which make the estimate of diagnostic performance less precise and less definitive.
Thus, omitting the third term even in the case of a large registry would make the estimate of the variance of the completeness index to be larger (more conservative).
Therefore, the increase between 2000 and 2011 is substantially overestimated; the authors could have contacted the Danish National Board of Health to make the estimate of missing operations more qualified.
The International Conference on Harmonisation E9 guidelines [ 16] discuss the importance of minimising bias in the design of trials, with 'bias' defined as "the systematic tendency of any factors associated with the design, conduct, analysis and interpretation of the results of clinical trials to make the estimate of a treatment effect deviate from its true value".
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These two weights were multiplied to produce the final weight for each individual and applied to make the estimates of scale validity more reflective of the screened population.
This would make the estimates of the cost-effectiveness of EHC conservative and could lead to higher savings than those predicted.
This will almost certainly make the estimates of genetic diversity in the far eastern (central Eurasian) populations unreliable as they are distantly related to the SNP discovery populations.
Moreover, the strong correlation between season and exposure, particularly for the trimester-specific exposure variables, was likely to make the estimates of our regression models adjusted for season instable.
However, as described in Text S1, further analyses suggest that our estimate of the power is conservative making the estimate of δ an underestimate.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com