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The visible effect of such clumping is that it adds heterogeneity and would make the dose response relationship less steep.
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Previous computational studies have shown that stochastic fluctuations could obscure the threshold of the switching behavior of a bistable system, making the dose response less switch-like [ 82, 83].
Two conditions make the dose-response part of mixture risk assessment difficult, lack of data on mixture dose-response relationships, and the need to address risk from combinations of chemicals because of public demands and statutory requirements.
These trials were made initially, prior to establishing the dose response curve to pheromone and plant odors, and therefore they did not necessarily fit the response thresholds.
Concentration estimates for C. burnetii are made jointly with estimates of the dose response parameters in a hierarchical Bayesian framework.
With decrease in K5 (Figure 7b) or increase in nH5 (Figure 7c) in Equation 2, the dose response can be made to be bistable over a wide range of ammonium sulphate concentration.
For example, most guideline studies only examine three treatment doses, which is not sufficient to make a conclusive judgment about the shape of the dose response curve.
Two observations can be made from the dose-response secretion patterns obtained from CTL clones 003 and SLY-10.
Another thing: pharmaceutical researchers are often looking at something they call "the dose response".
An estimate was made of dose response, considered to be present if the two highest concentrations both produced significant differences from the solvent controls.
The idea that the dose makes the poison, says Blumberg, "makes the assumption that the dose-response curve must be linear.
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