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They could now make the bacterium incorporate a novel kind of amino acid unit into its proteins, although they have not yet done so, to Dr. Joyce's disappointment.
A new study suggests that this protein dubbed BPSL1549 could make the bacterium 100 times more lethal than microbes engineered to stop making the toxin.
In tomorrow's Science, researchers report that they can decresase the incidence and severity of S. aureus infections in mice by blocking the ativity of a protein called RAP, which controls the production of toxins and other proteins that make the bacterium pathogenic.
In most cases these changes will also make the bacterium less fit.
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An additional set of mutations were necessary in the beginning; the final step was multiplying the gene inside the DNA to make the bacteria much more efficient in their absorption of citrate.
But by changing the surrounding magnetic field using an extended set-up coupled to an MRI machine, Martel and his colleagues were able to make the bacteria propel themselves in any direction they wanted.
The goal, says Campbell, was to make the bacteria produce mammoth hemoglobin in the lab.
That alone, however, doesn't necessarily make the bacteria capable of producing lots of sclareol.
If we can do that, we can make the bacteria sensitive to antibiotics".
Then the researchers did something they knew would make the bacteria unhappy: They started removing the oxygen from the water.
The effect of swarming is to make the bacteria congregate into groups and move as concentric patterns with high bacterial density.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com