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Ultrastructural investigation demonstrated that vesiculated efferent nerve endings make synaptic contact with the outer hair cells in the organ of Corti and with type II hair cells in the vestibular end-organs.
Besides growth factor effects on functional maturation it is likely that precursor cells are driven towards differentiation by the neurons that make synaptic contact with them.
These include thin unmyelinated C-fibers and myelinated Aδ-fibers, whose central terminals make synaptic contact with second order neurons that are at the origin of pain-related pathways [25].
The integration of glomeruli expressing different receptors occurs within each subdomain only and no study has reported, to our knowledge, evidence that any AOB neuron -projection or interneuron- would make synaptic contact with terminals from both subpopulations.
Because A-type horizontal cells make synaptic contact exclusively with cones, these observations indicate that the circadian clock in the mammalian retina substantially increases rod input to A-type horizontal cells at night by enhancing rod-cone coupling.
On the other hand, according to the same model, blockade of presynaptic A2AR localized in the cortico-striatal glutamatergic terminals that make synaptic contact with the direct MSN should decrease motor activity (by inhibiting glutamate release).
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These neurons make synaptic contacts with spiny neostriatal projection neurons.
As indicated in Fig. 4a, immature photoreceptors (both cones and rods) initially make synaptic contacts with the output layer of the developing retina at the inner plexiform layer (Johnson et al. 1999).
Upon arrival, DA fibers make synaptic contacts throughout the LGE and cortex, with axonal branching, pruning and synaptogenesis continuing into the first weeks of postnatal development.
This anatomy resembles that of hair cells, the force-sensitive epithelial cells of the inner ear that make synaptic contacts with afferent terminals.
Simultaneous intracellular staining of the LDS interneuron and its presynaptic mechanosensory afferents in the same preparation [17] has suggested that the afferent fibers make synaptic contacts with the interneuron at its distal dendrites.
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