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Although this may make statistical sense [ 116], it involves permuting the best fit-line away from the original biological data.
In our view, including such studies does not make statistical sense and we suggest that meta-analyses more generally may benefit from the exclusion of such poorly powered studies from the outset.
Pooling states together in a single empirical model with fixed effects to produce some "national" results may not make statistical sense when there is interest in the considerable heterogeneity that exists across the states [ 31].
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Critics have argued that turning up more small oddities may not necessarily be helpful, given that many are so rare that it will be hard to make any statistical sense of them.
The former remark was made in the context of rejecting the null hypothesis at the 5% level for significance and the latter presumably implied that mean t-statistics and z-scores were compared between groups, which makes no statistical sense.
It is not necessarily true that what makes best statistical sense or utility is what is best for describing possible outcomes for patients, including benefits alongside risks [ 32].
Another class of reporting error were those that simply made no statistical sense in the context they were reported: e.g. "…there was no difference in the incidence among the corresponding groups (chi-squared test, p = 0.05)…", and "…there were no significant differences in the mean T-score or Z-score between the patients and controls…".
Any additional risk-adjustment would stratify the small collectives into even smaller groups making no more statistical sense.
We will examine histograms of relevant variables from each dataset to check the spread, mean, median, and skewedness, and the consistency of these properties across datasets, before reaching a decision about whether it makes clinical or statistical sense to combine the data.
When events are rare, you need very large numbers, very long studies, or both, to accumulate enough such outcomes to make sense, let alone statistical sense, of the findings.
It makes little mathematical or statistical sense to compare index levels that way, considering that the index has roughly doubled over the past two years.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com