Sentence examples for make significant therapeutic from inspiring English sources

The broad intra- and inter-familial variability observed in OPA1 disease only serves to encapsulate several fundamental questions relating to tissue specificity, secondary genetic modifiers and possible environmental influences all of which need to be addressed if we are to make significant therapeutic inroads, not only for DOA, but for other multi-systemic nuclear mitochondrial disorders.

Further, both receptor and site of action of drug at BBB require better drug designs that could not only enhance its activity and selectivity but also make significant increase in the therapeutic index of drug [ 129] (Table 1).

Psilocybin could also have significant therapeutic uses.

These findings have significant therapeutic implications.

It opens the door to widespread downstream applications with the potential to make significant advances in novel avenues for therapeutic intervention in both Huntington's disease and trinucleotide expansion disorders in general.

Each of the eight inaugural ONES awardees is poised to make significant contributions to knowledge in the environmental health sciences, with potential therapeutic, preventive, or policy translational applications.

Formulation and delivery strategies that can improve the narrow therapeutic window of such compounds have the potential to make significant advances in treatment regimens.

Did we make significant progress?

All of these inventions are concerned with nanotechnology as applied to cancer and all have the potential to make a significant therapeutic impact on the health of cancer patients.

Each drug database made significant contributions to therapeutic target identification, with the maximum contribution from DrugBank (173), followed by TTD (57) and PharmGKB (15).

Advances in technology and the increasing availability of both diagnostic and therapeutic facilities have made significant contributions to this achievement.