Exact(1)
The analogues that make several interactions in the molecular docking studies were synthesized in the laboratory for further studies [13].
Similar(58)
The nucleotide corresponding to G130 is a U in the U4 snRNA Sm site, which is accommodated into the nucleotide binding pocket in SmD1 (Leung et al., 2011 ); (G ), U131 base is accommodated in a pocket consisting of SmD2 L3 residues His62 and Asn64, and L5 residue Arg102; (H ), G132 makes several interactions with the ribose phosphate backbone of neighbouring nucleotides.
The critical dimerization motif residues Leu and Leu are conserved in TRPM7, where the equivalent Leu and Leu make several hydrophobic interactions with four kinase domain residues (Gln, Ala, Leu and Leu) and a non-catalytic N-terminal residue (Leu) within the dimerization pocket.
In the complex, S02030 makes several canonical interactions: the O1 oxygen of S02030 is bound in the oxyanion hole, and the R1 amide group makes key interactions with conserved residues Asn152 and Gln120.
Furthermore, the protein binding patterns between 11a and AChE/BACE 1 showed that it makes several essential interactions with the enzymes.
That residue in Bim (R153) makes several additional interactions with BaxΔC21 in the α4– α5 loop region and accounts for an ~5-fold tighter binding of BaxΔC21 to BimBH3 than to BidBH3.
The crystal structure of PRMT4 bound to 41 revealed that the terminal l-alaninamide moiety mimics the arginine guanidinium group and makes several polar interactions with PRMT4, including the carboxyl groups of the double E-loop residues E258 and E267.
They do actually make several gestures towards AR: the tablets have holographic projections that support gestural interaction, there's a desk-based hologram device that Cullen uses, and Elsie employs a Google Glass-esque wearable.
We make several contributions.
But we make several simplifications.
Sequential trials make several tests.
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