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"We make our methodologies and research public explicitly because we expect and want people to investigate and challenge them – as we have for the past 25 years," she wrote in an email.
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We're always looking every year to try to find ways to tweak the list and to make our methodology a little bit more sound and make a little bit more sense.
In order to make our methodology robust to class imbalance (when there is an unequal number of cases and controls in the dataset), we implemented balanced accuracy as the fitness metric [ 25].
In summary, the process of primary data collection of both expenditure and activity indicators outlined in this paper and the emphasis on assessing data reliability by means of continuous interactions among researchers and LHAs' professionals make our methodology applicable to all Italian Regions and to OECD countries.
Authors' response: Again, we apologize for not making our methodology sufficiently clear.
Therefore, this made our methodology strongly reliable in that the RA-associated gene identified by our hypothesis-free approach was functionally strongly relevant to the pathogenesis of RA.
The urgent need to quickly and effectively monitor the health of the public makes our methodology a potentially plausible and useful surveillance approach for health professionals.
That is why the method becomes independent of the choice of the various substrates within the conscensus pathway and makes our methodology quite a general one without centering around any specific model of the system.
Indeed, recent tools as Cufflinks [ 49] can predict alternative transcripts and individual introns, making our methodology extremely recent and useful to improve genome annotations also in absence of canonical ESTs (generally produced by Sanger sequencing).
We also make our pedagogical goals, methods, and reasoning explicit for the faculty with whom we collaborate, disseminate the results of our research and assessment, and aim to make our research methodologies transparent.
However, assumptions made in our methodology and uncertainties and inaccuracies in our data may have introduced biases into our estimates, the impact of which is not fully captured in the confidence intervals presented.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com