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According to the stochastic resonance framework, the presence of neuronal noise can make neurons more sensitive to a given range of weak inputs.
Instead, it seems to make neurons more or less likely to fire, by changing the electrical potential of nerve-cell membranes.
It can make neurons more likely to fire or form new connections, he and others believe.
This may make neurons more prone to damage over time, he says.
This scenario results in an increase of extracellular glutamate which in principle is expected to make neurons more excitable and thus more prone to fire.
Koh wondered if tPA might make neurons more sensitive to the high levels of zinc released in injured areas.
Similar(51)
High dose Aβ42 significantly reduced the AP-threshold and shallowed the AHP, making neurons more excitable.
In contrast, high dose Aβ42 significantly reduced the AP-threshold and shallowed the AHP, making neurons more excitable.
Besides the sustained production of pathogenic substances, astrocytes fail to provide their neuro-supportive functions, making neurons more vulnerable to toxic molecules.
It is expected that at least some of these mutations cause disease through a partial loss of PGRN function, potentially by making neurons more vulnerable to neurodegeneration through subtle decreases in neurotrophic support.
This emerging structure and differentiation of cell properties was, however, decreased by strongly patterned visual stimulation, which reduced cell-to-cell variability, making neurons more similar to each other electrophysiologically.
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