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"make it unsuitable" is a correct and usable part of a sentence in written English.
It can be used in various contexts to mean to transform something into something that is not appropriate or not fitting for a particular purpose or situation. Example sentence: "The music playing in the background was too loud and energetic, making it unsuitable for a quiet and intimate dinner party."
Exact(51)
MQ was found to provide a high level of protection between the ages 2 11 months (PE 38.1% 955% CI 11.8, 56.5), but concerns about its tolerability in infants may make it unsuitable for IPTi in its current formulation.
Rice milk, for instance, is heat stable, but its overtones of sweetness make it unsuitable for savoury sauces and soups.
Thus, despite agomelatine's apparent equal efficacy to standard antidepressants, its costs and monitoring requirements make it unsuitable as a first line treatment.
We find that although Oases-M produces the highest gene coverage among popular assembly packages, its high redundancy and chimera rate make it unsuitable for phylogenomic purposes, even with extensive post processing.
Although the results obtained with IL-1Ra in patients with type 2 diabetes are encouraging, IL-1Ra has characteristics that make it unsuitable for the treatment of type 2 diabetes, such as its short half-life and injection-site reactions (9).
Why might that make it unsuitable for recreational use? f.
Similar(9)
The Kinetoscope launched the motion-picture industry, but its technical limitations made it unsuitable for projection.
However, the major disadvantage of PFGE is its low portability making it unsuitable for interlaboratory comparisons.
Although TRUS is more convenient than MP-MRI and has a lower cost, its low sensitivity makes it unsuitable for screening a large patient population [ 13].
Right heart catherisation (RHC) is currently the only confirmatory test for PAH, but its invasive nature makes it unsuitable for screening.
Furthermore, its value fluctuates wildly, making it unsuitable for everyday purchases like coffee and cab fare.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com