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"My preference would be for the court to rule that it is cruel and unusual punishment, which would make it prohibitive under the US constitution".
That kind of deal might interest the Yankees, although Mondesi's contract could make it prohibitive even to them.
Moreover, such laws reduce the ability of drug makers to quickly communicate with specialists about new drugs for rare diseases, a situation that could make it prohibitive for, say, a small biotechnology company with a tiny sales force to market a breakthrough medication, said Randy Frankel, the vice president for external affairs at IMS Health.
Think about the proverbial sustainable house of a rich, ecologically enlightened manager, located somewhere in a green isolated valley close to a forest and lake, with solar energy, use of waste as manure, windows open to natural light, etc: the costs of building such a house (to the environment, not only financial costs) make it prohibitive to the large majority.
"For borrowers on the fringe — low credit score, erratic documentation, high debt loads, et cetera — mortgage money may actually be available but the other terms and conditions that need to be jumped to have access to that financing make it prohibitive," said Keith Gumbinger, vice president of the financial publisher HSH Associates.
While erlotinib has a relatively benign toxicity profile, the expected dermatological complications [ 58] and unknown long-term effects will likely still make it prohibitive to use this particular drug for preventive purposes without time limits.
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This is an irrevocable change, bringing the NHS into the scope of European competition law, making it prohibitive to remove these "business opportunities" for private companies.
The small numbers also made it prohibitive to restrict the sample to just children.
Fully Homomorphic Encryption [25] would be ideal as it allows query execution on encrypted data and is completely secure, however, its high computation cost makes it prohibitive in practice.
Its price, anywhere from $2 billion to more than $5 billion depending on the plan, made it prohibitive.
What is available, though, is expensive, making it prohibitive for many merchants, especially those that do not sell luxury goods.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com