Sentence examples for make it non-functional from inspiring English sources

Previously, we demonstrated that when RA signal cannot be integrated at RARα, because RARα is either not expressed, or has acquired genetic mutations that make it non-functional, the chromatin associated with RARβ2 falls into an aberrant exacerbated state of repression, which is unresponsive to RA [9].

Typically, these mutations are truncating and tend to destroy the protein product or make it non-functional.

A comparative analysis of the rsp-2 gene and the 205-bp region of the gene found in the ITR sequence, revealed that the Turmoil-1 sequence has accumulated several point mutations within the 5' splice site that make it non-functional, whereas the 3' splice site of the intron remains intact (the mutations in the 5' splice site region are marked in red in Figure 1B).

For instance, the sex-determining region (SRY gene) of the Y chromosome may be transferred to an X chromosome, resulting in an XX normal male, or it may undergo mutation making it non-functional, resulting in an XY female.

You can't make it smaller without making it non-functional — so make it bigger.

Pseudo-gene has some deleterious mutations, which makes it non-functional.

There is a frame shift mutation in Rv2160A in M. tuberculosis that makes it non-functional in this species.

For ligand elongation we inserted two, three or four Ig domains from human CD2, mouse CD22 containing a mutation that makes it non-functional and human CD4, respectively.

"We've purposely made it non-covert.

This makes it non-partisan.

"It will be enormously difficult to make it truly functional.