Sentence examples for make it highly difficult from inspiring English sources

The party's rules for proportional allocation make it highly difficult for her to erase Mr. Obama's pledged delegate lead, even if she sweeps the final 10 contests.

Technically, criminal courts can only deal with individual responsibility, which makes it highly difficult to link a foreign state to the crime.

The decentralized outlook is what makes this technology so awesome, but it also makes it highly difficult to tame.

However, DMA keeps paper archives of all the reimbursement cases, making it highly difficult and time consuming to identify the relevant cases to fit the case vignettes.

The genetic heterogeneity and the complicated molecular mechanism underlying tumor progression have made it highly difficult to develop sustainable approaches for cancer therapy.

Owing to the diffuse distribution of intense neuropil staining of AQP4, we could not clearly discriminate AQP4-immunoreactive astrocytes with or without a contact with Aβ, making it highly difficult to count exactly the number of AQP4-expressing astrocytes located in the proximity to Aβ plaques.

It is found that the adsorption of most considered noble-metal single atoms is very strong at the hollow site above the center of the acetylenic ring of the graphyne sheet and their diffusion away from this site towards its neighboring sites is rather difficult, which makes it highly possible to realize well-ordered and uniformly distributed noble-metal single-atom catalysts on graphyne.

This time, companies were complaining about high personal income taxes, which make it difficult to recruit highly skilled employees.

It admits that it would be "highly problematic to make it more difficult for people to leave" that country.

Their detailed and highly variable nature make it particularly difficult for a system to change or create them realistically.

Together, these three features make it difficult to explain how a highly heritable and highly maladaptive phenotype can persist in the population with a remarkably stable prevalence around 1%, which is too high to be explained by a simple pattern of random mutation [11] [13].